Dad dropped a “new” (new to him, that is) MOTU 8282 Mk II off with me a few days ago complaining that it was rebooting randomly. A quick Google search turned up this is a relatively known issue, and that the LM1117-3.3 (3.3V regulator) basically starts to flake out after a few years, and causes issues.
I opened the unit, and indeed, the PCB around the LM1117 was brown from heat. After the unit running for a while, the LM1117 was over 90C. They’re feeding about 9V into the regulator (which is pretty high for a 3.3V regulator), and apparently drawing a fair bit of current to get it that hot. Before replacing the regulator, I wanted to confirm the failure. Knowing it was intermittent, and the reboot only took about 5 seconds, I set up a webcam in front of the unit with motion tracking software, and had it email me anytime the screen changed. Within a few hours, I’d captured half a dozen reboots. Once it starts rebooting, it rarely lasts more than 10 minutes without rebooting again.